Publications
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Dr. Mosconi's work includes over 15 years at the cutting edge of peer-reviewed brain aging research with a strong focus on Alzheimer's prevention. Selected publications from over 100 articles include:
2021
Mishra A, Wang Y, Yin F, Vitali F, Rodgers KE, Soto M, Mosconi L, Wang T, Brinton RD. A tale of two systems: Lessons learned from mid-life aging with implications for Alzheimer’s prevention and treatment. Aging Reviews 2021; in press.
Schelbaum E, Loughlin L, Jett S, Zang C, Jang G, Malviya N, Hristov H, Pahlajani S, Dyke J, Kamel H, Isaacson R, Brinton RD, Mosconi L. Association of reproductive history with brain MRI biomarkers of dementia risk in midlife. Neurology 2021; in press.
Mosconi L, Berti V, Dyke J, Schelbaum E, Jett S, Loughlin L, Jang G, Rahman A, Hristov H, Pahlajani S, Andrews R, Matthews D, Etingin O, Ganzer C, de Leon MJ, Isaacson R, Brinton RD. Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition. Scientific Reports 2021;11: e10867.
Vidoni ED, Choi IY, Lee P, Reed G, Zhang N, Pleen J, Mahnken JD, Clutton J, Becker A, Sherry E, Bothwell R, Anderson H, Harris RA, Brooks W, Wilkins HM, Mosconi L, Burns JM, Swerdlow RH. Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients. Alzheimers & Dementia 2021 Jan;17(1):7-17.
2020
Rahman A, Schelbaum E, Hoffman K, Diaz I, Hristov H, Andrews R, Jett S, Jackson H, Lee A, Sarva H, Pahlajani S, Matthews D, Dyke J, de Leon MJ, Isaacson RS, Brinton RD, Mosconi L. Sex-driven modifiers of Alzheimer’s risk: a multi-modality brain imaging study. Neurology 2020;95:e166-178.
Brinton RD, Mosconi L, Lee C, Vradenburg G. The Paradox of Precision Medicine. Adv Geriatr Med Res 2020;2(4):e200026.
2019
Rahman A, Jackson H, Hristov H, Isaacson RS, Saif N, Shetty T, Etingin O, Henchcliffe C, Brinton RD, Mosconi L. Sex and gender driven modifiers of Alzheimer’s: the role for estrogenic control across age, race, medical and lifestyle factors. Frontiers in Aging Neuroscience 2019; 11:315.
Kam K, Parekh A, Sharma RA, Andrade A, Lewin M, Castillo B, Bubu OM, Chua NJ, Miller MD, Mullins AE, Glodzik L, Mosconi L, Gosselin N, Prathamesh K, Chen Z, Blennow K, Zetterberg H, Bagchi N, Cavedoni B, Rapoport DM, Ayappa I, de Leon MJ, Petkova E, Varga AW, Osorio RS. Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau. Mol Neurodegener. 2019;14(1):10.
Mosconi L, Diaz I, Rahman A, Scheyer O, Xian W, Webb H, Vallabhajosula S, Isaacson RS, de Leon MJ, Brinton RD. The perimenopause to menopause transition influences Alzheimer’s biomarker progression: a 3-year brain imaging study. PLOS One 2019;13:e0207885.
Isaacson RS, Hristov H, Saif N, Hackett K, Hendrix S, Melendez J, Safdieh J, Fink M, Thambisetty M, Sadek G, Bellara S, Lee P, Berkowitz C, Rahman A, Meléndez-Cabrero J, Caesar E, Cohen R, Lu PL, Dickson SP, Hwang MJ, Scheyer O, Mureb M, Schelke MW, Niotis K, Greer CE, Attia P, Mosconi L, Krikorian R. Individualized clinical management of patients at risk for Alzheimer's dementia. Alzheimers Dement 2019;15:1588-1602.
2018
Berkowitz CL, Mosconi L, Rahman A, Scheyer O, Hristov H, Isaacson RS. Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach. J Prev Alzheimers Dis. 2018;5(4):245-252
Berti V, Walters M, Sterling J, Quinn CG, Logue M, Andrews R, Matthews DC, Osorio RS, Pupi A, Vallabhajosula S, Isaacson RS, de Leon MJ, Mosconi L. Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults. Neurology 2018;90:e1789-1798.
Hackett K, Krikorian R, Giovannetti T, Melendez-Cabrero J, Rahman A, Caesar EE, Chen JL, Hristov H, Seifan A, Mosconi L, Isaacson RS. Utility of the NIH Toolbox for assessment of prodromal Alzheimer's disease and dementia. Alzheimers Dement (Amst). 2018 Nov 2;10:764-772.
Isaacson RS, Ganzer CA, Hristov H, Hackett K, Caesar E, Cohen R, Kachko R, Meléndez-Cabrero J, Rahman A, Scheyer O, Hwang MJ, Berkowitz C, Hendrix S, Mureb M, Schelke MW, Mosconi L, Seifan A, Krikorian R. The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach. Alzheimers Dement. 2018;14:1663-1673.
Isaacson RS, Seifan A, Haddox CL, Mureb M, Rahman A, Scheyer O, Hackett K, Caesar E, Chen JL, Isaacson J, McInnis M, Mosconi L, Safdieh J. Using social media to disseminate education about Alzheimer's prevention & treatment: a pilot study on Alzheimer's universe (www.AlzU.org). J Commun Healthc. 2018;11(2):106-113.
Mosconi L, Brinton RD. How would we combat menopause as an Alzheimer’s disease risk factor? [Editorial] Expert Reviews of Neurotherapeutics 2018;18:689-691.
Mosconi L, Rahman A, Diaz I, Wu X, Scheyer O, Hristov HW, Vallabhajosula S, Isaacson RS, de Leon MJ, Brinton RD. Increased Alzheimer's risk during the menopause transition: A 3-year longitudinal brain imaging study. PLoS One. 2018 Dec 12;13(12):e0207885.
Mosconi L, Walters M, Sterling J, Quinn C, McHugh P, Andrews A, Matthews DC, Ganzer C, Osorio RS, Isaacson RI, de Leon MJ, Convit A. Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer's disease: a cross-sectional study of middle-aged adults from the broader New York City area. British Medical Journal (open access) 2018; http://dx.doi.org/10.1136/bmjopen-2017-019362.
Scheyer O, Rahman A, Hristov H, Berkowitz C, Isaacson RS, Brinton RD, Mosconi L. Female Sex and Alzheimer’s Risk: The Menopause Connection. J Prev Alzheimers Dis 2018; 5: 225–230.
Schelke MW, Attia P, Palenchar DJ, Kaplan B, Mureb M, Ganzer CA, Scheyer O, Rahman A, Kachko R, Krikorian R, Mosconi L, Isaacson RS. Mechanisms of Risk Reduction in the Clinical Practice of Alzheimer's Disease Prevention. Frontiers in Aging Neuroscience 2018;10:96.
Walters MJ, Sterling J, Quinn C, Ganzer C, Osorio RS, Andrews RD, Matthews DC, Vallabhajosula S, de Leon MJ, Isaacson RS, Mosconi L. Associations of lifestyle and vascular risk factors with Alzheimer's brain biomarker changes during middle age: a 3-year longitudinal study in the broader New York City area. BMJ Open. 2018;8:e023664.
2017
Mosconi L, Berti V, Quinn C, McHugh P, Petrongolo G, Pupi A, Osorio R, Isaacson RS, Vallabhajosula S, de Leon MJ, Brinton RD. Altered Brain bioenergetics in the Perimenopause to Menopause transition: Implications for the increased Alzheimer’s risk in women. PLoS ONE 2017; 12(10): e0185926.
Mosconi L, Berti V, Quinn C, McHugh P, Petrongolo G, Varsavsky I, Osorio RS, Pupi A, Vallabhajosula S, Isaacson RS, de Leon MJ, Brinton RD. Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging. Neurology 2017; 89(13):1382-1390.
Walters M, Hackett K, Caesar E, Isaacson RS, Mosconi L. Role of Nutrition to Promote Healthy Brain Aging and Reduce Alzheimer’s Disease Risk. Current Nutrition Reports 2017; 6:63–71.
Sharma RA, Varga AW, Bubu OM, Pirraglia E, Kam K, Parekh A, Wohlleber M, Miller MD, Lewis C, Tweardy S, Buj M, Yau PL, Sadda R, Mosconi L, Li Y, Butler T, Glodzik L, Fieremans E, Blennow K, Zetterberg H, Lu SE, Badia SG, Romero S, Rosenzweig I, Gosselin N, Girardin JL, Rapoport DM, de Leon MJ, Ayappa I, Osorio RS. Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly: A Longitudinal Study. American Journal of Respiratory and Critical Care Medicine 2017; in press.
2016
Osorio RS, Ducca EL, Wohlleber M, Tanzi EB, Gumb T, Twumasi A, Tweardy S, Lewis C, Fischer E, Koushky V, Cuartero-Toledo M, Sheik MO, Pirraglia E, Zetterberg H, Blennow K, Lu SE, Mosconi L, Glodzik L, Schuetz S, Varga AW, Ayappa I, Rapoport D, de Leon MJ. Orexin-A is associated with increases in cerebrospinal fluid P-Tau in cognitively normal elderly. Sleep 2016; 39:1253-1260.
Varga AW, Wohlleber ME, Giménez S, Romero S, Alonso JF, Ducca EL, Kam K, Lewis C, Tanzi EB, Tweardy S, Kishi A, Parekh A, Fischer E, Gumb T, Alcolea D, Fortea J, Lleó A, Blennow K, Zetterberg H, Mosconi L, Glodzik L, Pirraglia E, Burschtin OE, de Leon MJ, Rapoport DM, Lu SE, Ayappa I, Osorio RS. Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid Aβ42 Levels in Cognitively Normal Elderly. Sleep 2016pii: sp-00140-16.
Glodizk L, Rusinek H, Kamer A, Pirraglia E, Tsui W, Mosconi L, Li Y, McHugh P, Murray J, Williams S, Osorio RS, Randall C, Butler T, Deshpande A, Vallabhajolusa S, de Leon M. Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects. Alzheimer's & Dementia. 2016 2:95-104.
Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS, for the Down Syndrome Biomarker Initiative and the Alzheimer’s Disease Neuroimaging Initiative. Dissociation of Down’s syndrome and Alzheimer’s disease effects with imaging. Alzheimer’s & Dementia 2016; 2:69-81.
Butler T, Li Y, Tsui W, Friedman D, Maoz A, Wang X, Harvey P, Tanzi E, Morim S, Kang Y, Mosconi L, Talos D, Kuzniecky R, Vallabhajosula S, thesen T, Glodzik L, Ichise M, Silbersweig D, Stern E, de Leon M, French J. Transient and chronic seizure-induced inflammation in human focal epilepsy. Epilepsia 2016; 57:e191-194.
2015
Mosconi L, McHugh PF. Let food be thy medicine: diet, nutrition and risk of Alzheimer’s disease. Current Nutrition Reports 2015; 4:126-135.
Li Y, Tsui W, Rusinek H, Butler T, Mosconi L, Pirraglia E, Mozley D, Vallabhajosula S, Harada R, Furumoto S, Furukawa K, Arai H, Kudo Y, Okamura N, de Leon M. Cortical Lamina Binding of PET Amyloid and Tau tracers in Alzheimer's disease. Journal of Nuclear Medicine 2015; 56:270-3.
De Leon MJ, Pirraglia E, Osorio R, Glodzik L, Li Y, Mosconi L, Saint Louis LA, Zetterberg H, Blennow K. The trajectory of CSF amyloid beta levels in preclinical load. Neurodegenerative Diseases 2015;15:244-245.
Osorio RM, Gumb T, Pirraglia E, Varga A, Shou-en L, Lim J, Wohlleber M, Ducca E, Koushyk V, Glodizk L, Mosconi L, Ayappa I, Rapoport D, de Leon MJ. Sleep Disordered Breathing Advances Cognitive Decline in the Elderly. Neurology 2015; 84:1964-71.
Glodzik L, Rusinek H, Tsui W, Osorio RS, Williams S, Randall C, Spector N, Murray J, Pirraglia E, Mosconi L, de Leon MJ. Reduced retention of Pittsburgh compound B in white matter lesions. European Journal of Nuclear Medicine and Molecular Imaging 2015; 42:97-102.
De Leon MJ, Glodzik L, Mosconi L, Osorio, R, Kamer A, De Santi S, Shulman M, Li Y, Tsui W, Butler T, Okamura N, Rusinek H. Imaging Alzheimer's disease: The Evolution of Biomarkers. In Brain Mapping: An Encyclopedic Reference 2015; pp. 619-623.
De Leon MJ, Glodzik L, Mosconi L, Osorio R, Shulman M, Li Y, Tsui W, Butler T, De Santi S, Kamer A, Okamura N, Rusinek H. Alzheimer’s disease: the evolution of biomarkers. Brain Mapping: An Encyclopedic Reference (BRNM), Elsevier 2015; in press
2014
Mosconi L, Murray J, Davies M, Williams S, Pirraglia E, Spector N, Tsui WH, Li Y, Butler T, Osorio R, Glodzik L, Vallabhajosula S, McHugh P, Marmar CR, de Leon MJ. Nutrient intake and brain biomarkers of Alzheimer’s disease in at-risk cognitively normal individuals: a cross-sectional neuroimaging pilot study. British Medical Journal 2014; 4:e004850.
Mosconi L, Murray J, Tsui WH, Li Y, Spector N, Goldowsky A, Williams S, Osorio R, McHugh P, Glodzik L, Vallabhajosula S, de Leon MJ. Brain imaging of cognitively individuals with two late-onset Alzheimer’s parents. Neurology 2014; 82:752-60.
Mosconi L, Murray J, Tsui WH, Li Y, Davies M, Williams S, Pirraglia E, Spector N, Osorio R, Glodzik L, McHugh P, de Leon MJ. Mediterranean diet and Magnetic Resonance Imaging-assessed brain atrophy in cognitively normal individuals at risk for Alzheimer’s disease. Journal of Prevention of Alzheimer’s disease 2014; 1: 23-32.
Mosconi L, Murray J, McHugh PF, de Leon MJ. Brain hypometabolism, oxidative stress, maternal transmission and risk of late-onset Alzheimer’s disease. In Studies on Alzheimer’s Disease, Oxidative Stress in Applied Basic Research and Clinical Practice. Eds. D. Praticò and P. Mecocci. Springer Science+Business Media New York, NY, 2014. Chapter 10. DOI 10.1007/978-1-62703-598-9_10.
Matthews DC, Davies M, Murray J, Tsui W, Li Y, Williams S, Lukic A, Andrews R, Vallabhajosula S, McHugh P, de Leon MJ, Mosconi L. Physical activity, Diet and biomarker-assessed risk of Alzheimer’s disease: a multi-modality brain imaging study. Advances in Molecular Imaging 2014; 4: 43-57.
Murray J Tsui WH, Li Y, McHugh P, Williams S, Cummings M, Pirraglia E, Solnes L, Osorio R, Glodzik L, Vallabhajosula S, Drzezga A, Minoshima S, de Leon MJ, Mosconi L. FDG and Amyloid PET in cognitively normal individuals at risk for late-onset Alzheimer’s disease. Advances in Molecular Imaging 2014; 4: 15-26.
Berti V, Murray J, Davies M, Spector N, Tsui WH, Li Y, Williams S, Pirraglia E, Vallabhajosula S, McHugh P, Pupi A, de Leon MJ, Mosconi L. Nutrient patterns and brain biomarkers of Alzheimer’s disease in cognitively normal individuals. Journal of Nutrition Health and Aging 2014; 19:413-423.
Berti V, A Pupi, Mosconi L. Normal Brain Variations and Benign Findings in FDG PET/CT imaging. PET Clinics 2014; 9(2):129-140
Glodzik L, Kuceyeski A, Rusinek H, Tsui W, Mosconi L, Osorio RS, Williams S, Randall C, Spector N, McHugh P, Murray J, Pirraglia E, Vallabhajolusa S, Raj A, de Leon MJ. Reduced glucose uptake and Aβ in brain regions with hyper-intensities in connected white matter. NeuroImage 2014; 100: 684-691.
Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chételat G, Dubois B, Dufouil C, Ellis KA, van der Flier WM, Glodzik L, van Harten A, de Leon MJ, McHugh P, Mielke MM, Molinuevo JL, Mosconi L, Osorio RS, Perrotin A, Petersen RC, Rabin LA, Rami L, Reisberg B, Rentz DM, Sachdev PS, de la Sayette V, Saykin AJ, Scheltens P, Shulman MB, Slavin MJ, Sperling RA, Stewart R, Uspenskaya O, Vellas B, Visser PJ, Wagner M.A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer’s and Dementia 2014; 10:844-852.
Osorio RM, Ayappa I, Mantua J, Gumb T, Varga A, Mooney AM, Burschtin O, Taxin Z, During E, Spector N, Biagioni M, Pirraglia E, Lau H, Zetterberg H, Blennow K, Lu SE, Mosconi L, Glodzik L, Rapoport DM, de Leon MJ. The interaction between sleep-disordered breathing and ApoE genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly. Neurobiology of Aging 2014; 35:1318-24.
2013
Mosconi L. Glucose metabolism in normal aging and Alzheimer’s disease. Methodological & physiologic considerations for PET studies. Clinical and Translational Imaging 2013; 1:217–233.
Mosconi L, Rinne JO, Tsui WH, Murray J, Li Y, Glodzik L, McHugh P, Williams S, Cummings M, Pirraglia E, Goldsmith SJ, Vallabhajosula S, Scheinin N, Viljanen T, Nagren K, de Leon MJ. Amyloid and metabolic PET imaging of cognitively normal adults with Alzheimer’s parents. Neurobiology of Aging 2013; 34:22-34.
Glodzik L, Mosconi L, Tsui W, De Santi S, Zinkowski R, Pirraglia E, Rich K, McHugh P, Li Y, Williams S, Ali F, Zetterberg H, Blennow K, Mehta P, de Leon MJ. Alzheimer's disease markers, hypertension and gray matter damage in normal elderly. Neurobiology of Aging 2013; 33:1215-27.
Protas HD, Chen K, Langbaum JBS, Fleisher AS, Alexander GE, Lee W, Bandy D, de Leon MJ, Mosconi L, Buckley S, Truran-Sacrey D, Schuff N, Weiner MW, Caselli RJ, Reiman EM. Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism and Hippocampal Volume in Cognitively Normal, Late-Middle Age Persons at Three Levels of Genetic Risk for Alzheimer’s Disease. JAMA Neurology 2013; 70:320-325.
Glodzik L, Rusinek H, Pirraglia E, McHugh P, Tsui W, Williams S, Cummings M, Li Y, Rich K, Randall C, Mosconi L, Osorio R, Murray J, Zetterberg H, Blennow K, de Leon M. Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly. Neurobiology of Aging 2014; 35:64-71.
Osorio RS, Pirraglia E, Gumb T, Mantua J, Ayappa I, Williams S, Mosconi L, Glodzik L, de Leon MJ. Imaging and Cerebrospinal Fluid Biomarkers in the Search for Alzheimer's disease Mechanisms. Neurodegenerative Disease 2013; 13(2-3):163-5.
3. Randall C, Mosconi L, Leon Md, Glodzik L. Cerebrospinal fluid biomarkers of Alzheimer’s disease in cognitively healthy elderly. Frontiers in Bioscience 2013; 18:1150-73.
Schmidt ME, Andrews R, Mosconi L, Matthews DC. In Vivo Imaging in Alzheimer’s Disease: Diagnosis and Use as Biomarker Endpoints. In Brain Imaging: Translational tools for CNS drug discovery, development and treatment. Ed. R. McArthur, Elsevier 2013; Chapter 5, page 131-174
2012
Mosconi L, Andrews RD, Matthews DC, and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Comparing brain amyloid deposition, glucose metabolism and atrophy in Mild Cognitive Impairment with and without a family history of dementia. Journal of Alzheimer’s disease 2013; 35:509-24.
Mosconi L, Tsui W, Murray J, McHugh P, Li Y, Williams S, Pirraglia E, Glodzik L, De Santi S, Vallabhajosula S, de Leon MJ. Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer’s disease. Neurobiology of Aging 2012; 33:624.e1-642.e9.
Berti V, Polito C, Borghammer P, Ramat S, Mosconi L, Vanzi E, De Cristofaro MT, De Leon M, Sorbi S, Pupi A. Alternative normalization methods demonstrate widespread cortical hypometabolism in untreated de novo Parkinson's disease. Q Journal of Nuclear Medicine 2012; 56:299-308.
2011
Mosconi L, de Leon MJ, Murray J, E L, J Lu, Javier E, McHugh P, Swerdlow RH. Reduced cytochrome oxidase activity in adult children of mothers with Alzheimer’s disease. Journal of Alzheimer’s disease 2011, 27:483-490.
Mosconi L, Berti V, McHugh P, Pupi A, De Santi S, de Leon MJ. A tale of two tracers: glucose metabolism and amyloid PET imaging in Alzheimer’s disease. Advances in Alzheimer’s disease 2011; 1: 219-234.Berti V, Mosconi L, Glodzik L, Li Y, Murray J, De Santi S, Pupi A, Tsui W, de Leon MJ. Structural brain changes in normal individuals with a maternal history of Alzheimer’s. Neurobiology of Aging 2011; 32: 2325.e17–2325.e26.
Mosconi L, McHugh PF FDG- and Amyloid-PET in Alzheimer’s disease: is the whole better than the sum of its parts? Quarterly Journal of Nuclear Medicine 2011; 55:250-264.
Berti V, Pupi A, Mosconi L. PET/CT in diagnosis of Movement disorders, In PET/CT applications in Non-Neoplastic Conditions, Eds. M. Hashefi & J. Katz. Annals of the New York Academy of Science, 2011, 1228: 93–108.
Berti V, Pupi A, Mosconi L. PET/CT in diagnosis of Dementia, In PET/CT applications in Non- Neoplastic Conditions, Eds. M. Hashefi & J. Katz. Annals of the New York Academy of Science, 2011, 1228: 81-92.
Pupi A, Mosconi L. Brain Amyloid Imaging: The Challenge of the Third Millennium. Quarterly Journal of Nuclear Medicine 2011; 55:223-224.
During E, Osorio R, Mosconi L, de Leon MJ. The concept of FDG-PET endophenotype in Alzheimer's disease. Neurological Sciences 2011; 32: 559-569
Brys, M; Glodzik, L; Mosconi, L; Switalski, R; De, Santi S; Pirraglia, E; Rich, K; Kim, B C; Mehta, P; Zinkowski, R; Pratico, D; Wallin, A; Zetterberg, H; Tsui, W H; Rusinek, H; Blennow, K; De, Leon M J. Quantitative structural MRI and CSF biomarkers in early diagnosis of Alzheimer's disease. Advances in Alzheimer's disease 2011; 1:141-152
2010
Mosconi L, Rinne JO, Tsui W, Berti V, Li Y, Murray J, Wang H, Scheinin N, Någren K, Williams S, Glodzik L, De Santi S, Vallabhajosula S, de Leon MJ. Increased fibrillar amyloid-β burden in normal individuals with a family history of late-onset Alzheimer’s. Proceedings of the National Academy of Sciences USA 2010, 107: 5949-54. [Article featured in the “Research Highlights” section of the June issue of Nature Reviews Neurology; Yates D. Alzheimer disease: maternal history of Alzheimer disease correlates with amyloid-beta deposition. Nat Rev Neurol 2010; 6:298]
Mosconi L, Glodzik L, Mistur R, McHugh P, Rich KE, Javier E, Williams S, Pirraglia E, De Santi S, Mehta PD, Zinkowski R, Blennow K, Pratico D, de Leon MJ. Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer’s. Biological Psychiatry, 2010; 68:913-921.
Mosconi L, Berti V, Swerdlow RH, Pupi A, Duara R, de Leon MJ. Maternal transmission of Alzheimer’s disease: Prodromal metabolic phenotype and the search for genes. Human Genomics 2010; 4: 170-193.
Mosconi L, Berti V, Glodzik L, Pupi A, De Santi S, de Leon MJ. Early detection of Alzheimer’s disease, with or without amyloid imaging. Journal of Alzheimer’s disease 2010; 20:843-845.
Glodzik L, Rusinek H, Brys M, Tsui WH, Switalski R, Mosconi L, Mistur R, Pirraglia E, de Santi S, Li Y, Goldowsky A, de Leon MJ. Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia. Journal of Cerebral Blood Flow & Metabolism 2010; 31:671-679.
Glodzik L, De Santi S, Tsui W, Mosconi L, Zinkowski R, Pirraglia E, Wang H, Li Y, Rich K, Zetterberg H, Blennow K, Mehta P, de Leon MJ. Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders. Neurobiology of Aging 2010; 32:2131-41.
Berti V, Osorio RM, Mosconi L, Li Y, De Santi S, de Leon MJ. The Early Detection of Alzheimer’s disease with PET imaging. Neurodegenerative Diseases 2010; 7:131-135.
Osorio RM,Berti V, Li Y, De Santi S, Mosconi L, de Leon MJ. The Early Detection of Alzheimer’s disease with PET imaging. Positron Emission Tomography Clinics 2010; 5: 15-32
2009
Mosconi L, Mistur R, Switalski R, Brys M, Glodzik L, Pirraglia E, Tsui WH, De Santi S, de Leon MJ. Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer’s. Neurology 2009; 72:513-20. Epub 2008 Nov 12 [Article featured in the “Highlights” section of the Dec 12th issue of Neurology; Related commentary in Neurology: Dhawan V, Eidelberg D. Mom and me: brain metabolism links Alzheimer disease to maternal genes. Neurology 2009; 72:513-20]
Mosconi L, Mistur R, Switalski R, Tsui WH, Glodzik L, Brys M, Li Y, Pirraglia E, De Santi S, Reisberg B, Wisniewski T, de Leon MJ. FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging 2009; 36:811-822.
Mistur R, Mosconi L, De Santi S, Guzman M, Li Y, Tsui W, de Leon MJ. Current challenges for the early detection of Alzheimer's disease: brain imaging and CSF studies. Journal of Clinical Neurology 2009; 5:153-166
Glodzik L, De Santi S, Rich K, Brys M, Pirraglia E, Switalski R, Mosconi L, Mistur R, Sadowski M, Zetterberg H, Blennow K, de Leon MJ. Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology. Journal of Alzheimer’s disease 2009, 18: 509-513.
Clerici F, Del Sole A, Chiti A, Maggiore L, Lecchi M, Pomati S, Mosconi L, Lucignani G, Mariani C. Cerebral metabolism similarities and differences in amnestic and non-amnestic Mild Cognitive Impairment: automated FDG-PET image analysis. Quarterly Journal of Nuclear Medicine 2009; 53: 646-657.
Brys M, Pirraglia E, Rich K, Rolstad S, Mosconi L, Switalski R, Glodzik-Sobanska L, De Santi S, Zinkowski R, Mehta P, Pratico D, Saint Louis LA, Wallin A, Blennow K, de Leon MJ. Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment. Neurobiology of Aging 2009, 30: 682-690.
Glodzik-Sobanska L, Pirraglia E, Brys M, de Santi S, Mosconi L, Rich KE, Switalski R, Louis LS, Sadowski MJ, Martiniuk F, Mehta P, Pratico D, Zinkowski RP, Blennow K, de Leon MJ. The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease. Neurobiology of Aging 2009; 30: 672-681.
Brys M, Glodzik L, Mosconi L, Switalski R, De Santi S, Pirraglia E, Rich K, Kim BC, Mehta P, Zinkowski R, Pratico D, Wallin A, Zetterberg H, Tsui WH, Rusinek H, Blennow K, de Leon MJ. Magnetic resonance imaging improves CSF biomarkers in the early detection of Alzheimer’s disease. Journal of Alzheimer’s Disease 2009; 16:351-362. Epub May 2008.
Zhan J, Brys M, Glodzik L, Tsui W, Javier E, Wegiel J, Kuchna I, Pirraglia E, Li Y, Mosconi L, Saint Louis LA, Switalski R, De Santi S, Kim BC, Wisniewski T, Reisberg B, Bobinski M, de Leon MJ. An Entorhinal Cortex Sulcal Pattern is Associated with Alzheimer's disease. Human Brain Mapping 2009; 30:874-82.
2008
Mosconi L, De Santi S, Li J, Tsui WH, Li Y, Boppana M, Laska E, Rusinek H, de Leon MJ. Hippocampal hypometabolism predicts cognitive decline from normal aging. Neurobiology of Aging 2008; 29: 676-692.
Mosconi L, De Santi S, Brys M, Tsui WH, Pirraglia E, Glodzik-Sobanska L, Rich KE, Switalski R, Mehta PD, Pratico D, Zinkowski R, Blennow K, de Leon MJ. Hypometabolism and altered CSF markers in normal ApoE-4 carriers with subjective memory complaints. Biological Psychiatry 2008; 63:609-618 [Cover art for the March 15th issue].
Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, Reiman EM, Holthoff V, Kalbe E, Sorbi S, Diehl-Schmid J, Perneczky R, Mariani C, Caselli R, Beuthien-Baumann B, Kurz A, Minoshima S, de Leon MJ. Multi-center standardized FDG-PET diagnosis of Mild Cognitive Impairment, Alzheimer’s disease, and Other Dementias. Journal of Nuclear Medicine 2008; 49:390-398.
Mosconi L, Pupi A, de Leon MJ. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer’s disease. Annals of the NY Academy of Sciences 2008; 1147: 180-195.
Apostolova LG, Mosconi L, Thompson PM, Green AE, Hwang K, Ramirez A, Mistur R, Tsui WH, de Leon MJ. Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal. Neurobiology of Aging 2008; 31:1077-88.
Silverman DHS, Mosconi L, Ercoli L, Chen W, Small GW. Positron Emission Tomography scans obtained for evaluation of cognitive dysfunction. Seminars in Nuclear Medicine 2008; 38:251-261.
Mistur R, Mosconi L, De Santi S, Li Y, Tsui W, de Leon MJ. Positron Emission Tomography in Alzheimer’s disease: early diagnosis and differentiation. Future Neurology 2008; 4: 23-38.
Li Y, Rinne JO, Mosconi L, Tsui W, Pirraglia E, Rusinek H, De Santi S, Kemppainen N, Nagren K, Kim BC, de Leon MJ. Automated regions of interest analysis of PIB and FDG PET studies in NL, MCI and AD. European Journal of Nuclear Medicine and Molecular Imaging 2008; 35:2169-81.
Reisberg B, Prichep L, Mosconi L, John ER, Glodzik-Sobanska L, Boksay I, Monteiro I, Torossian C, Vedvyas A, Ashraf N, Jamil IA, de Leon MJ. The pre-Mild Cognitive Impairment, Subjective Cognitive Impairment stage of Alzheimer’s disease. Alzheimer’s & Dementia (special issue in honor of Dr. Leon Thal) 2008; 4:98-108.
Mitsis EM, Bobinski M, Brys M, Glodzik L, De Santi S, Li Y, Kim BC, Mosconi L, de Leon MJ. Neuropathological and neuroimaging studies of the hippocampus in normal aging and in Alzheimer’s disease. In: Neurobiology of Mental Illness (3rd edition). Eds. D.S. Charney DS & E.J. Nestler. Oxford University Press, New York (NY), 2008. ISBN: 0195325338. ISBN-13: 978019532533
Del Sole A, Clerici F, Chiti A, Lecchi M, Mariani C, Maggiore L, Mosconi L, Lucignani G. Individual cerebral metabolic deficits in Alzheimer’s disease and amnestic Mild Cognitive Impairment: an FDG-PET study. European Journal of Nuclear Medicine and Molecular Imaging 2008; 35:1357-1366.
De Santi S, Pirraglia E, Barr W, Babb J, Williams S, Rogers K, Glodzik-Sobanska L, Brys M, Mosconi L, Reisberg B, Ferris S, de Leon MJ. Robust and Conventional Neuropsychological Norms: Diagnosis and Prediction of Age-Related Cognitive Decline. Neuropsychology 2008; 22:469-484.
2007
Mosconi L, Brys M, Switalski R, Mistur R, Glodzik L, Pirraglia E, Tsui WH, De Santi S, de Leon MJ. Maternal family history of Alzheimer’s disease predisposes to reduced brain glucose metabolism. Proceedings of the National Academy of Sciences USA 2007; 104:19067-19072. [Article featured in the “In This Issue” section of the Nov 27th issue of PNAS. Related commentary in PNAS: Swerdlow RH. PET sheds light on Alzheimer's disease genetic risk. Proc Natl Acad Sci USA 2007 Nov 27;104:18881-18882].
Mosconi L, Tsui WH, Pupi A, De Santi S, Drzezga A, Minoshima S, de Leon MJ. FDG-PET database of longitudinally confirmed healthy elderly improves detection of MCI and AD. Journal of Nuclear Medicine 2007; 48:1129–1134.
Mosconi L, Tsui WH, Rusinek H, De Santi S, Li Y, Wang GJ, Pupi A, Fowler J, de Leon MJ. Quantitation, regional vulnerability and kinetic modeling of brain glucose metabolism in mild Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging 2007; 34:1467-79.
Mosconi L, Pupi A. Energy-metabolism: Age, Alzheimer disease, and ApoE allele effects on brain glucose metabolism. In: New Encyclopedia of Neuroscience (3rd edition). Eds. L. Squire, T. Albright, F. Bloom, F. Gage, & N. Spitzer. Elsevier: Shannon, Ireland; 2007. ISBN: 978-0-08-045046-9.
Mosconi L, Brys M, Glodzik- Sobanska L, De Santi S, Rusinek H, de Leon MJ. Early detection of Alzheimer’s disease using neuroimaging. Experimental Gerontology 2007; 42:12-138.
De Leon MJ, Mosconi L, Logan J. Seeing what Alzheimer saw. Nature Medicine 2007; 13:129-131.
de Leon MJ, Mosconi L, Blennow K, De Santi S, Zinkowski R, Mehta PD, Pratico D, Tsui W, Saint Louis LA, Sobanska L, Brys M, Li Y, Rich K, Rinne J, Rusinek H. CSF and Imaging Studies in the Preclinical Diagnosis of Alzheimer’s Disease. Annals of the NY Academy of Sciences 2007; 1097:114-145.
de Leon MJ, Mosconi L, Blennow K, De Santi S, Zinkowski R, Mehta PD, Pratico D, Tsui W, Saint Louis LA, Sobanska L, Brys M, Li Y, Rich K, Rinne J, Rusinek H. Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease. In: Imaging and the aging brain. Malden, MA, US: Wiley-Blackwell Publishing, 2007; 114-118. ISBN: 978-1-57331-659-0.
de Leon MJ, Mosconi L, Li J, De Santi S, Yao Y, Tsui WH, Pirraglia E, Rich K, Javier E, Brys M, Sobanska L, Saint Louis LA, Pratico D. Longitudinal CSF isoprostane and MRI measures in the progression to AD. Journal of Neurology 2007; 254:1666-75.
Sigurdsson EM, Wadghiri YZ, Mosconi L, Blind JA, Knudsen E, Asuni A, Scholtzova H, Tsui WH, Li Y, Sadowski M, Turnbull DH, de Leon MJ, Wisniewski TM. A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice. Neurobiology of Aging 2008; 29:836-47. Epub 2007; doi:10.1016/j.neurobiolaging.2006.12.01.
Glodzik- Sobanska L, Li J, Mosconi L, Slowik A, Szczudlik A, Walecki J, Sobiecka B, de Leon MJ. Prefrontal N-Acetylaspartate and post-stroke recovery: a longitudinal proton spectroscopy study. AJNR American Journal of Neuroradiology 2007; 28:470-474.
Bracco L, Bessi V, Piccini C, Mosconi L, Pupi A, Sorbi S. Metabolic correlates of executive dysfunction: different patterns in mild and very mild Alzheimer’s disease. Journal of Neurology 2007; 254:1052-65.
2006
Mosconi L, Sorbi S, de Leon MJ, Li Y, Nacmias B, Myoung PS, Tsui W, Bessi V, Fayyazz M, Caffarra P, Pupi A. Hypometabolism exceeds atrophy in presymptomatic Familial Alzheimer’s disease. Journal of Nuclear Medicine 2006; 47:1778-86.
Mosconi L, De Santi S, Li Y, Zhan J, Li J, Tsui WH, Boppana M, de Leon MJ. Visual rating of the Medial Temporal Lobe on FDG-PET in Mild Cognitive Impairment and Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging 2006; 33:210-21.
de Leon MJ, De Santi S, Zinkowski R, Mehta PD, Pratico D, Segal S, Rusinek H, Li J, Tsui W, Saint Louis LA, Clark CM, Tarshish C, Lair L, Javier E, Rich K, Lesbre, Mosconi L, Reisberg B, Sadowski M, DeBernadis JF, Kerkman J, Hampel H, Wahlund LO, Davies P. Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiology of Aging 2006; 27:394-401.
Brys M, De Santi S, Mosconi L, Rich K, de Leon MJ. CSF biomarkers for Mild Cognitive Impairment. Aging Health 2006; 2:111-121.
2005
Mosconi L. Brain metabolism as an early and specific marker in the diagnosis of Alzheimer disease. European Journal of Nuclear Medicine and Molecular Imaging 2005; 32:486-510.
Mosconi L, Tsui W-H, De Santi S, Rusinek H, Li J, Convit A, Li Y, de Leon MJ. Reduced Hippocampal metabolism in MCI and AD: Automated FDG-PET Image Analysis. Neurology 2005; 64:1860-1867.
Mosconi L, Herholz K, Prohovnik I, Sorbi S, Nacmias B, De Cristofaro MTR, Fayyaz M, Bracco L, Pupi A. Metabolic interaction between APOE genotype and onset age in Alzheimer disease. Implications for brain reserve. Journal of Neurology, Neurosurgery and Psychiatry 2005; 76:15-23.
Pupi A, Mosconi L, Nobili F, Sorbi S. Towards the validation of Functional Neuroimaging as a potential biomarker for Alzheimer’s disease. Implications for drug development. Molecular Imaging and Biology 2005; 7:59-68.
Glodzik- Sobanska L, Rusinek H, Mosconi L, Li Y, Zhan J, De Santi S, Convit A, Rich K, Brys M, de Leon MJ. Structural quantitative imaging in the diagnosis of Alzheimer’s disease. Neuroimaging Clinics of North America 2005; 15:803-26.
2004
Mosconi L, De Santi S, Rusinek H, Convit A, de Leon MJ. Magnetic resonance and PET studies in the early diagnosis of Alzheimer's disease. Expert Review of Neurotherapeutics 2004; 4:831-849.
Mosconi L, Perani D, Sorbi S, Herholz K, Nacmias B, Holthoff V, Salmon E, Baron JC, Padovani A, Borroni B, Franceschi M, Bracco L, Pupi A. MCI conversion to Dementia and the APOE genotype: a prediction study with FDG-PET. Neurology 2004; 63:2332-2340.
Mosconi L, Sorbi S, Nacmias B, De Cristofaro MTR, Fayyaz M, Cellini E, Bagnoli S, Bracco L, Herholz K, Pupi A. Brain metabolic decreases related to the dose of the ApoE E4 allele in Alzheimer’s Disease. Journal of Neurology, Neurosurgery and Psychiatry 2004; 75:370-376.
Mosconi L, Pupi A, De Cristofaro MTR, Fayyaz M, Sorbi S, Herholz K. Functional interactions of the entorhinal cortex. An FDG-PET study on normal aging and Alzheimer’s disease. Journal of Nuclear Medicine 2004; 45:382-392.
Mosconi L, Sorbi S, Nacmias B, De Cristofaro MTR, Fayyaz M, Piccini C, Bracco L, Herholz K, Pupi A. Age and APOE genotype interaction in Alzheimer’s disease. An FDG-PET study. Psychiatry Research: Neuroimaging. 2004; 130:141-150.
2003
Mosconi L, Sorbi S, Nacmias B, De Cristofaro MTR, Fayyaz M, Cellini E, Bagnoli S, Bracco L, Herholz K, Pupi A. Brain metabolic differences between sporadic and familial Alzheimer's disease. Neurology 2003; 61:1138-1140.
Mosconi L, La Malfa GP, Ragazzoni A, Rossi L. Panic Attacks Disorder: from Event-Related Potentials to an “attentive” explanation. Journal of Neurology 2002;12:1-7.
La Malfa GP, Mosconi L, Ragazzoni A, Rossi L. Event-Related Potentials (P300) in Panic Attacks Disorder: a cognitive perspective. Italian Journal of Psychopathology 2002; 8:19-23